[HTML][HTML] Cloning and Characterization of MEK6, a Novel Member of the Mitogen-activated Protein Kinase Kinase Cascade (∗)
B Stein, H Brady, MX Yang, DB Young… - Journal of Biological …, 1996 - ASBMB
Mitogen-activated protein kinases are members of a conserved cascade of kinases involved
in many signal transduction pathways. They stimulate phosphorylation of transcription
factors in response to extracellular signals such as growth factors, cytokines, ultraviolet light,
and stress-inducing agents. A novel mitogen-activated protein kinase kinase, MEK6, was
cloned and characterized. The complete MEK6 cDNA was isolated by polymerase chain
reaction. It encodes a 334-amino acid protein with 82% identity to MKK3. MEK6 is highly …
in many signal transduction pathways. They stimulate phosphorylation of transcription
factors in response to extracellular signals such as growth factors, cytokines, ultraviolet light,
and stress-inducing agents. A novel mitogen-activated protein kinase kinase, MEK6, was
cloned and characterized. The complete MEK6 cDNA was isolated by polymerase chain
reaction. It encodes a 334-amino acid protein with 82% identity to MKK3. MEK6 is highly …
