[HTML][HTML] Role of the isoforms of CCAAT/enhancer-binding protein in the initiation of phosphoenolpyruvate carboxykinase (GTP) gene transcription at birth
C Croniger, M Trus, K Lysek-Stupp, H Cohen… - Journal of Biological …, 1997 - ASBMB
The gene for phosphoenolpyruvate carboxykinase (PEPCK), a target of CCAAT/enhancer-
binding protein-α (C/EBPα) and-β (C/EBPβ), begins to be expressed in the liver at birth. Mice
homozygous for a deletion in the gene for CEBPα (C/EBPα−/− mice) die shortly after birth of
hypoglycemia, with no detectable hepatic PEPCK mRNA and negligible hepatic glycogen
stores. Half of the mice homozygous for a deletion in the gene for CEBPβ (C/EBPβ−/− mice)
have normal glucose homeostasis (phenotype A), and the other half die at birth of …
binding protein-α (C/EBPα) and-β (C/EBPβ), begins to be expressed in the liver at birth. Mice
homozygous for a deletion in the gene for CEBPα (C/EBPα−/− mice) die shortly after birth of
hypoglycemia, with no detectable hepatic PEPCK mRNA and negligible hepatic glycogen
stores. Half of the mice homozygous for a deletion in the gene for CEBPβ (C/EBPβ−/− mice)
have normal glucose homeostasis (phenotype A), and the other half die at birth of …