Glucocorticoids regulate the induction of phosphoenolpyruvate carboxykinase (GTP) gene transcription during diabetes
JE Friedman, JS Yun, YM Patel, MM McGrane… - Journal of Biological …, 1993 - ASBMB
The hormonal regulation of transcription of the phosphoenolpyruvate carboxykinase
(GTP)(4.1. 1.32)(PEPCK) gene during diabetes was studied using transgenic mice
containing a chimeric gene consisting of segments of the PEPCK promoter (-2000/+ 73,-
460/+ 73,-355/+ 73) linked to bovine growth hormone (bGH) reporter gene. The effect of
diabetes and insulin on transgenic mice containing a mutation in cAMP regulatory
sequences at-90/-82 and-250/-234 was also studied. In addition, we analyzed the …
(GTP)(4.1. 1.32)(PEPCK) gene during diabetes was studied using transgenic mice
containing a chimeric gene consisting of segments of the PEPCK promoter (-2000/+ 73,-
460/+ 73,-355/+ 73) linked to bovine growth hormone (bGH) reporter gene. The effect of
diabetes and insulin on transgenic mice containing a mutation in cAMP regulatory
sequences at-90/-82 and-250/-234 was also studied. In addition, we analyzed the …
