[HTML][HTML] Niemann-Pick C1 Like 1 (NPC1L1) is the intestinal phytosterol and cholesterol transporter and a key modulator of whole-body cholesterol homeostasis
HR Davis, L Zhu, LM Hoos, G Tetzloff… - Journal of Biological …, 2004 - ASBMB
Niemann-Pick C1 Like 1 (NPC1L1) is a protein localized in jejunal enterocytes that is critical
for intestinal cholesterol absorption. The uptake of intestinal phytosterols and cholesterol
into absorptive enterocytes in the intestine is not fully defined on a molecular level, and the
role of NPC1L1 in maintaining whole body cholesterol homeostasis is not known. NPC1L1
null mice had substantially reduced intestinal uptake of cholesterol and sitosterol, with
dramatically reduced plasma phytosterol levels. The NPC1L1 null mice were completely …
for intestinal cholesterol absorption. The uptake of intestinal phytosterols and cholesterol
into absorptive enterocytes in the intestine is not fully defined on a molecular level, and the
role of NPC1L1 in maintaining whole body cholesterol homeostasis is not known. NPC1L1
null mice had substantially reduced intestinal uptake of cholesterol and sitosterol, with
dramatically reduced plasma phytosterol levels. The NPC1L1 null mice were completely …
