Differential expression patterns of claudins, tight junction membrane proteins, in mouse nephron segments
As the first step in understanding the physiologic functions of claudins (tight junction integral
membrane proteins) in nephrons, the expression of claudin-1 to-16 in mouse kidneys was
examined by Northern blotting. Among these claudins, only claudin-6,-9,-13, and-14 were
not detectable. Claudin-5 and-15 were detected only in endothelial cells. Polyclonal
antibodies specific for claudin-7 and-12 were not available. Therefore, the distributions of
claudin-1,-2,-3,-4,-8,-10,-11, and-16 in nephron segments were examined with …
membrane proteins) in nephrons, the expression of claudin-1 to-16 in mouse kidneys was
examined by Northern blotting. Among these claudins, only claudin-6,-9,-13, and-14 were
not detectable. Claudin-5 and-15 were detected only in endothelial cells. Polyclonal
antibodies specific for claudin-7 and-12 were not available. Therefore, the distributions of
claudin-1,-2,-3,-4,-8,-10,-11, and-16 in nephron segments were examined with …