Epidermal growth factor receptors: critical mediators of multiple receptor pathways
PO Hackel, E Zwick, N Prenzel, A Ullrich - Current opinion in cell biology, 1999 - Elsevier
PO Hackel, E Zwick, N Prenzel, A Ullrich
Current opinion in cell biology, 1999•ElsevierRecently, the receptor for epidermal growth factor (EGF) was identified as a downstream
element in different signaling pathways. This expanded its classical function as a receptor
for EGF-like ligands to a role as mediator of diverse signaling systems and as a switch point
of a cellular communication network. In addition, several downstream targets,(eg Smad
proteins and STATs) into which signals from synergistic and antagonistic signaling pathways
converge, were identified.
element in different signaling pathways. This expanded its classical function as a receptor
for EGF-like ligands to a role as mediator of diverse signaling systems and as a switch point
of a cellular communication network. In addition, several downstream targets,(eg Smad
proteins and STATs) into which signals from synergistic and antagonistic signaling pathways
converge, were identified.
Recently, the receptor for epidermal growth factor (EGF) was identified as a downstream element in different signaling pathways. This expanded its classical function as a receptor for EGF-like ligands to a role as mediator of diverse signaling systems and as a switch point of a cellular communication network. In addition, several downstream targets, (e.g. Smad proteins and STATs) into which signals from synergistic and antagonistic signaling pathways converge, were identified.
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