[HTML][HTML] CaMKIIδ isoforms differentially affect calcium handling but similarly regulate HDAC/MEF2 transcriptional responses
T Zhang, M Kohlhaas, J Backs, S Mishra… - Journal of Biological …, 2007 - ASBMB
The δ B and δ C splice variants of Ca 2+/calmodulin-dependent protein kinase II (CaMKII),
which differ by the presence of a nuclear localization sequence, are both expressed in
cardiomyocytes. We used transgenic (TG) mice and CaMKII expression in cardiomyocytes to
test the hypothesis that the CaMKIIδ C isoform regulates cytosolic Ca 2+ handling and the δ
B isoform, which localizes to the nucleus, regulates gene transcription. Phosphorylation of
CaMKII sites on the ryanodine receptor (RyR) and on phospholamban (PLB) were increased …
which differ by the presence of a nuclear localization sequence, are both expressed in
cardiomyocytes. We used transgenic (TG) mice and CaMKII expression in cardiomyocytes to
test the hypothesis that the CaMKIIδ C isoform regulates cytosolic Ca 2+ handling and the δ
B isoform, which localizes to the nucleus, regulates gene transcription. Phosphorylation of
CaMKII sites on the ryanodine receptor (RyR) and on phospholamban (PLB) were increased …