[HTML][HTML] Regulation of Jak kinases by intracellular leptin receptor sequences
Leptin signals the status of body energy stores via the leptin receptor (LR), a member of the
Type I cytokine receptor family. Type I cytokine receptors mediate intracellular signaling via
the activation of associated Jak family tyrosine kinases. Although their COOH-terminal
sequences vary, alternatively spliced LR isoforms (LRa–LRd) share common NH 2-terminal
sequences, including the first 29 intracellular amino acids. The so-called long form LR (LRb)
activates Jak-dependent signaling and is required for the physiologic actions of leptin. In this …
Type I cytokine receptor family. Type I cytokine receptors mediate intracellular signaling via
the activation of associated Jak family tyrosine kinases. Although their COOH-terminal
sequences vary, alternatively spliced LR isoforms (LRa–LRd) share common NH 2-terminal
sequences, including the first 29 intracellular amino acids. The so-called long form LR (LRb)
activates Jak-dependent signaling and is required for the physiologic actions of leptin. In this …
