SNARE-mediated membrane fusion
YA Chen, RH Scheller - Nature reviews Molecular cell biology, 2001 - nature.com
YA Chen, RH Scheller
Nature reviews Molecular cell biology, 2001•nature.comSNARE proteins have been proposed to mediate all intracellular membrane fusion events.
There are over 30 SNARE family members in mammalian cells and each is found in a
distinct subcellular compartment. It is likely that SNAREs encode aspects of membrane
transport specificity but the mechanism by which this specificity is achieved remains
controversial. Functional studies have provided exciting insights into how SNARE proteins
interact with each other to generate the driving force needed to fuse lipid bilayers.
There are over 30 SNARE family members in mammalian cells and each is found in a
distinct subcellular compartment. It is likely that SNAREs encode aspects of membrane
transport specificity but the mechanism by which this specificity is achieved remains
controversial. Functional studies have provided exciting insights into how SNARE proteins
interact with each other to generate the driving force needed to fuse lipid bilayers.
Abstract
SNARE proteins have been proposed to mediate all intracellular membrane fusion events. There are over 30 SNARE family members in mammalian cells and each is found in a distinct subcellular compartment. It is likely that SNAREs encode aspects of membrane transport specificity but the mechanism by which this specificity is achieved remains controversial. Functional studies have provided exciting insights into how SNARE proteins interact with each other to generate the driving force needed to fuse lipid bilayers.
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