Autoantibodies in childhood opsoclonus–myoclonus syndrome
F Blaes, MG Pike, B Lang - Journal of neuroimmunology, 2008 - Elsevier
Opsoclonus–myoclonus syndrome or Dancing Eyes syndrome (OMS/DES) is a rare
neurological disorder of children, which associates with neuroblastoma (NB) in
approximately 50% of cases. We examined sera from five patients with (OMS-NB+) and five
with out NB (OMS-NB−) for autoantibodies. OMS-NB− IgG bound to the surface of a NB cell
line, whereas IgG from OMS-NB+ and from NB patients without OMS/DES bound only to
permeabilised cells. Both OMS-NB+ and OMS-NB-reduced proliferation of NB cells. We also …
neurological disorder of children, which associates with neuroblastoma (NB) in
approximately 50% of cases. We examined sera from five patients with (OMS-NB+) and five
with out NB (OMS-NB−) for autoantibodies. OMS-NB− IgG bound to the surface of a NB cell
line, whereas IgG from OMS-NB+ and from NB patients without OMS/DES bound only to
permeabilised cells. Both OMS-NB+ and OMS-NB-reduced proliferation of NB cells. We also …
