Rag-1-dependent cells are necessary for 1, 25-dihydroxyvitamin D3 prevention of experimental autoimmune encephalomyelitis
FE Nashold, KA Hoag, J Goverman… - Journal of …, 2001 - Elsevier
Multiple sclerosis (MS) is a demyelinating disease involving genetic and environmental risk
factors. Geographic, genetic, and biological evidence suggests that one environmental risk
factor may be lack of vitamin D. Here, we investigated how 1, 25-dihydroxyvitamin D3 (1, 25-
(OH) 2D3) inhibits experimental autoimmune encephalomyelitis (EAE), an MS model. The
experiments used adoptive transfer of TCR-transgenic (TCR1) cells specific for myelin basic
protein (MBP) peptide into unprimed recipients. When unprimed TCR1 splenocytes were …
factors. Geographic, genetic, and biological evidence suggests that one environmental risk
factor may be lack of vitamin D. Here, we investigated how 1, 25-dihydroxyvitamin D3 (1, 25-
(OH) 2D3) inhibits experimental autoimmune encephalomyelitis (EAE), an MS model. The
experiments used adoptive transfer of TCR-transgenic (TCR1) cells specific for myelin basic
protein (MBP) peptide into unprimed recipients. When unprimed TCR1 splenocytes were …