Influence of the HLA-DRB1 genotype on antibody development to interferon beta in multiple sclerosis
D Buck, S Cepok, S Hoffmann, V Grummel… - Archives of …, 2011 - jamanetwork.com
Objective To determine relevant HLA-DRB1 alleles associated with the susceptibility of anti–
interferon beta antibody development in a large patient cohort. Design In a case-control
study, HLA-DRB1 genotyping was performed in a discovery cohort (n= 268) and a validation
cohort (n= 825). Setting Patients were recruited in Germany by primary care physicians and
neurologists and were mainly of Northern European heritage. Patients All patients had a
diagnosis of multiple sclerosis and were receiving long-term interferon beta therapy. Main …
interferon beta antibody development in a large patient cohort. Design In a case-control
study, HLA-DRB1 genotyping was performed in a discovery cohort (n= 268) and a validation
cohort (n= 825). Setting Patients were recruited in Germany by primary care physicians and
neurologists and were mainly of Northern European heritage. Patients All patients had a
diagnosis of multiple sclerosis and were receiving long-term interferon beta therapy. Main …