[HTML][HTML] Vaso-occlusive and prothrombotic mechanisms associated with tumor hypoxia, necrosis, and accelerated growth in glioblastoma
DJ Brat, EG Van Meir - Laboratory investigation, 2004 - Elsevier
Glioblastoma (GBM) has explosive biologic properties with rapid clinical progression
leading to death. Its distinguishing pathologic features, necrosis with surrounding
pseudopalisades and microvascular hyperplasia, are believed to be instrumental to its
accelerated growth. Microvascular hyperplasia arises in response to the secretion of
proangiogenic factors by hypoxic pseudopalisades and allows for peripheral neoplastic
expansion. Mechanisms underlying necrosis and hypoxia remain obscure, but vaso …
leading to death. Its distinguishing pathologic features, necrosis with surrounding
pseudopalisades and microvascular hyperplasia, are believed to be instrumental to its
accelerated growth. Microvascular hyperplasia arises in response to the secretion of
proangiogenic factors by hypoxic pseudopalisades and allows for peripheral neoplastic
expansion. Mechanisms underlying necrosis and hypoxia remain obscure, but vaso …
