[HTML][HTML] Regulation of MyoD activity and muscle cell differentiation by MDM2, pRb, and Sp1
CS Guo, C Degnin, TA Fiddler, D Stauffer… - Journal of Biological …, 2003 - ASBMB
Muscle cell differentiation is controlled by a complex set of interactions between tissue
restricted transcription factors, ubiquitously expressed transcription factors, and cell cycle
regulatory proteins. We previously found that amplification of MDM2 in rhabdomyosarcoma
cells interferes with MyoD activity and consequently inhibits overt muscle cell differentiation
(1). Recently, we found that MDM2 interacts with Sp1 and inhibits Sp1-dependent
transcription and that pRb can restore Sp1 activity by displacing MDM2 from Sp1 (2). In this …
restricted transcription factors, ubiquitously expressed transcription factors, and cell cycle
regulatory proteins. We previously found that amplification of MDM2 in rhabdomyosarcoma
cells interferes with MyoD activity and consequently inhibits overt muscle cell differentiation
(1). Recently, we found that MDM2 interacts with Sp1 and inhibits Sp1-dependent
transcription and that pRb can restore Sp1 activity by displacing MDM2 from Sp1 (2). In this …
