[HTML][HTML] Hypoxia-inducible transcription factor-2α in endothelial cells regulates tumor neovascularization through activation of ephrin A1
T Yamashita, K Ohneda, M Nagano, C Miyoshi… - Journal of Biological …, 2008 - ASBMB
The hypoxia-inducible transcription factors (HIF)-1α and-2α mediate responses to hypoxia,
such as tumor neovascularization. To determine the function of HIF-2α in vascular
endothelial cells (ECs), we examined vascular formation in HIF-2α knockdown (kd/kd) mice
transplanted with tumors. We observed that both the tumor size and the number of large
vessels growing within transplanted melanomas were significantly reduced in kd/kd
recipients compared with wild-type (WT) mice. In contrast, we observed a similar extent of …
such as tumor neovascularization. To determine the function of HIF-2α in vascular
endothelial cells (ECs), we examined vascular formation in HIF-2α knockdown (kd/kd) mice
transplanted with tumors. We observed that both the tumor size and the number of large
vessels growing within transplanted melanomas were significantly reduced in kd/kd
recipients compared with wild-type (WT) mice. In contrast, we observed a similar extent of …