Regulation of skeletal myogenesis by Notch
MF Buas, T Kadesch - Experimental cell research, 2010 - Elsevier
MF Buas, T Kadesch
Experimental cell research, 2010•ElsevierNotch signaling has emerged as a key player in skeletal muscle development and
regeneration. Simply stated, Notch signaling inhibits differentiation. Accordingly, fine-tuning
the pathway is essential for proper muscle homeostasis. This review will address various
aspects of Notch signaling, including our current views of the core pathway, its effects in
muscle, its interactions with other signaling pathways, and its relationship with ageing.
regeneration. Simply stated, Notch signaling inhibits differentiation. Accordingly, fine-tuning
the pathway is essential for proper muscle homeostasis. This review will address various
aspects of Notch signaling, including our current views of the core pathway, its effects in
muscle, its interactions with other signaling pathways, and its relationship with ageing.
Notch signaling has emerged as a key player in skeletal muscle development and regeneration. Simply stated, Notch signaling inhibits differentiation. Accordingly, fine-tuning the pathway is essential for proper muscle homeostasis. This review will address various aspects of Notch signaling, including our current views of the core pathway, its effects in muscle, its interactions with other signaling pathways, and its relationship with ageing.
Elsevier