[HTML][HTML] Differential expression of pro-and antiangiogenic factors in mouse strain-dependent hypoxia-induced retinal neovascularization
CK Chan, LN Pham, J Zhou, C Spee, SJ Ryan… - Laboratory …, 2005 - Elsevier
Clinical observations suggest that genetic factors may influence heterogeneity of angiogenic
responses in cardiovascular disease, proliferative diabetic retinopathy, and neoplasia.
Experiments among mouse strains using a corneal micropocket assay indicate that extent of
angiogenesis may be genetically determined. Here, we established the strain-dependence
of hypoxia-induced retinal angiogenesis in multiple mouse strains which paralleled the rank
order found for bFGF-induced corneal angiogenesis. Using quantitative real-time RT-PCR …
responses in cardiovascular disease, proliferative diabetic retinopathy, and neoplasia.
Experiments among mouse strains using a corneal micropocket assay indicate that extent of
angiogenesis may be genetically determined. Here, we established the strain-dependence
of hypoxia-induced retinal angiogenesis in multiple mouse strains which paralleled the rank
order found for bFGF-induced corneal angiogenesis. Using quantitative real-time RT-PCR …