[HTML][HTML] Prostaglandin synthase-1 and prostaglandin synthase-2 are coupled to distinct phospholipases for the generation of prostaglandin D2 in activated mast cells
ST Reddy, HR Herschman - Journal of Biological Chemistry, 1997 - ASBMB
Aggregation of IgE cell surface receptors on MMC-34 cells, a murine mast cell line, induces
the synthesis and secretion of prostaglandin D 2 (PGD 2). Synthesis and secretion of PGD 2
in activated MMC-34 cells occurs in two stages, an early phase that is complete within 30
min after activation and a late phase that reaches a maximum about 6 h after activation. The
early and late phases of PGD 2 generation are mediated by prostaglandin synthase 1
(PGS1) and prostaglandin synthase 2 (PGS2), respectively. Arachidonic acid, the substrate …
the synthesis and secretion of prostaglandin D 2 (PGD 2). Synthesis and secretion of PGD 2
in activated MMC-34 cells occurs in two stages, an early phase that is complete within 30
min after activation and a late phase that reaches a maximum about 6 h after activation. The
early and late phases of PGD 2 generation are mediated by prostaglandin synthase 1
(PGS1) and prostaglandin synthase 2 (PGS2), respectively. Arachidonic acid, the substrate …
