Detection of the major urinary metabolite of prostaglandin D2 in the circulation: demonstration of elevated levels in patients with disorders of systemic mast cell …
JA Awad, JD Morrow, LJ Roberts II - Journal of allergy and clinical …, 1994 - Elsevier
The symptoms and hemodynamic alterations that accompany episodes of systemic mast cell
activation have been largely attributed to excessive prostaglandin (PG) D 2 release.
Quantification of the major urinary metabolite of PGD 2 has been invaluable in elucidating a
role for PGD 2 in these clinical entities and in the biochemical evaluation of systemic
mastocytosis. With the use of a modified mass spectrometric assay for the major urinary
metabolite of PGD 2, this metabolite was detected in plasma from 10 normal volunteers …
activation have been largely attributed to excessive prostaglandin (PG) D 2 release.
Quantification of the major urinary metabolite of PGD 2 has been invaluable in elucidating a
role for PGD 2 in these clinical entities and in the biochemical evaluation of systemic
mastocytosis. With the use of a modified mass spectrometric assay for the major urinary
metabolite of PGD 2, this metabolite was detected in plasma from 10 normal volunteers …
