[HTML][HTML] MicroRNA-21 is a downstream effector of AKT that mediates its antiapoptotic effects via suppression of Fas ligand
D Sayed, M He, C Hong, S Gao, S Rane, Z Yang… - Journal of Biological …, 2010 - ASBMB
MicroRNA-21 (miR-21) is highly up-regulated during hypertrophic and cancerous cell
growth. In contrast, we found that it declines in cardiac myocytes upon exposure to hypoxia.
Thus, the objective was to explore its role during hypoxia. We show that miR-21 not only
regulates phosphatase and tensin homologue deleted on chromosome 10 (PTEN), but also
targets Fas ligand (FasL). During prolonged hypoxia, down-regulation of miR-21 proved
necessary and sufficient for enhancing expression of both proteins. We demonstrate here for …
growth. In contrast, we found that it declines in cardiac myocytes upon exposure to hypoxia.
Thus, the objective was to explore its role during hypoxia. We show that miR-21 not only
regulates phosphatase and tensin homologue deleted on chromosome 10 (PTEN), but also
targets Fas ligand (FasL). During prolonged hypoxia, down-regulation of miR-21 proved
necessary and sufficient for enhancing expression of both proteins. We demonstrate here for …
