Cyclooxygenase-2 expression associated with severity of PanIN lesions: a possible link between chronic pancreatitis and pancreatic cancer
R Albazaz, CS Verbeke, SH Rahman, MJ McMahon - Pancreatology, 2005 - Elsevier
Abstract Background: Cyclooxygenase-2 (COX-2) is a key modulatory molecule in
inflammation and neoplasia. Increasing evidence suggests a role for COX-2 in pancreatic
cancer (PAC). However, expression of COX-2 in pancreatic intraepithelial neoplasia
(PanIN), the precursor lesion of PAC which is often present in chronic pancreatitis (CP), has
received little attention. Method: COX-2 immuno-staining was performed on sections of PAC
(n= 26), CP (n= 34), PanIN (n= 68) and normal pancreas (n= 11). Sections were also stained …
inflammation and neoplasia. Increasing evidence suggests a role for COX-2 in pancreatic
cancer (PAC). However, expression of COX-2 in pancreatic intraepithelial neoplasia
(PanIN), the precursor lesion of PAC which is often present in chronic pancreatitis (CP), has
received little attention. Method: COX-2 immuno-staining was performed on sections of PAC
(n= 26), CP (n= 34), PanIN (n= 68) and normal pancreas (n= 11). Sections were also stained …
