The IκB kinase complex (IKK) is central to the activation of NF-κB, a critical transcription
factor governing expression of genes involved in cell proliferation and anti-apoptotic
responses. Mice with genetic disruptions of the Ikkβ or Ikkγ gene loci die during
embryogenesis because of severe hepatic apoptosis. We now show that Ikkβ gene
deficiency promotes migration and proliferation of mouse embryo fibroblast cells.
Morphological analyses revealed an unusual protrusion of the cytoplasm in Ikkβ-/-cells …