Acute liver necrosis following overdose of paracetamol.
DG Davidson, WN Eastham - British medical journal, 1966 - ncbi.nlm.nih.gov
DG Davidson, WN Eastham
British medical journal, 1966•ncbi.nlm.nih.govAlthough paracetamol was first described more than seventy years ago, it is only in the last
fifteen that it has become popular as a mild analgesic. It has been shown to be the principal
breakdown product of phenacetin and to have an analgesic effect of similar magnitude. Liver
damage following abuse of phenacetin is quoted by Kasanen and Forsstrom (1964), but in
humans this complication has not been noted with paracetamol, although liver necrosis has
been reported in rats (Boyd and Bereczky, 1966).
fifteen that it has become popular as a mild analgesic. It has been shown to be the principal
breakdown product of phenacetin and to have an analgesic effect of similar magnitude. Liver
damage following abuse of phenacetin is quoted by Kasanen and Forsstrom (1964), but in
humans this complication has not been noted with paracetamol, although liver necrosis has
been reported in rats (Boyd and Bereczky, 1966).
Although paracetamol was first described more than seventy years ago, it is only in the last fifteen that it has become popular as a mild analgesic. It has been shown to be the principal breakdown product of phenacetin and to have an analgesic effect of similar magnitude. Liver damage following abuse of phenacetin is quoted by Kasanen and Forsstrom (1964), but in humans this complication has not been noted with paracetamol, although liver necrosis has been reported in rats (Boyd and Bereczky, 1966).
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