[HTML][HTML] Abnormal cardiac structure and function in mice expressing nonphosphorylatable cardiac regulatory myosin light chain 2
A Sanbe, JG Fewell, J Gulick, H Osinska… - Journal of Biological …, 1999 - ASBMB
A role for myosin phosphorylation in modulating normal cardiac function has long been
suspected, and we hypothesized that changing the phosphorylation status of a cardiac
myosin light chain might alter cardiac function in the whole animal. To test this directly,
transgenic mice were created in which three potentially phosphorylatable serines in the
ventricular isoform of the regulatory myosin light chain were mutated to alanines. Lines were
obtained in which replacement of the endogenous species in the ventricle with the …
suspected, and we hypothesized that changing the phosphorylation status of a cardiac
myosin light chain might alter cardiac function in the whole animal. To test this directly,
transgenic mice were created in which three potentially phosphorylatable serines in the
ventricular isoform of the regulatory myosin light chain were mutated to alanines. Lines were
obtained in which replacement of the endogenous species in the ventricle with the …