Involvement of protein kinase C and Src family tyrosine kinase in Gαq/11-induced activation of c-Jun N-terminal kinase and p38 mitogen-activated protein kinase
M Nagao, J Yamauchi, Y Kaziro, H Itoh - Journal of Biological Chemistry, 1998 - ASBMB
Mitogen-activated protein kinases (MAPKs) are activated by various extracellular stimuli.
The signaling pathways from G protein-coupled receptors to extracellular signal-regulated
kinase have been partially elucidated, whereas the mechanisms by which G protein-coupled
receptors stimulate c-Jun N-terminal kinase (JNK) and p38 MAPK activities remain largely
unknown. We have recently demonstrated that the signal from G q/11-coupled m1
muscarinic acetylcholine receptor to p38 MAPK is mediated by both Gα q/11 and Gβγ in …
The signaling pathways from G protein-coupled receptors to extracellular signal-regulated
kinase have been partially elucidated, whereas the mechanisms by which G protein-coupled
receptors stimulate c-Jun N-terminal kinase (JNK) and p38 MAPK activities remain largely
unknown. We have recently demonstrated that the signal from G q/11-coupled m1
muscarinic acetylcholine receptor to p38 MAPK is mediated by both Gα q/11 and Gβγ in …
