[HTML][HTML] Potentiation of Helicobacter pylori CagA protein virulence through homodimerization
L Nagase, N Murata-Kamiya, M Hatakeyama - Journal of biological …, 2011 - ASBMB
Chronic infection with Helicobacter pylori cagA-positive strains is associated with atrophic
gastritis, peptic ulceration, and gastric carcinoma. The cagA gene product, CagA, is
delivered into gastric epithelial cells via type IV secretion, where it undergoes tyrosine
phosphorylation at the EPIYA motifs. Tyrosine-phosphorylated CagA binds and aberrantly
activates the oncogenic tyrosine phosphatase SHP2, which mediates induction of elongated
cell morphology (hummingbird phenotype) that reflects CagA virulence. CagA also binds …
gastritis, peptic ulceration, and gastric carcinoma. The cagA gene product, CagA, is
delivered into gastric epithelial cells via type IV secretion, where it undergoes tyrosine
phosphorylation at the EPIYA motifs. Tyrosine-phosphorylated CagA binds and aberrantly
activates the oncogenic tyrosine phosphatase SHP2, which mediates induction of elongated
cell morphology (hummingbird phenotype) that reflects CagA virulence. CagA also binds …
