TRPC1 inhibits apoptotic cell degeneration induced by dopaminergic neurotoxin MPTP/MPP+
S Selvaraj, JA Watt, BB Singh - Cell calcium, 2009 - Elsevier
Disturbances in Ca2+ homeostasis have been implicated in a variety of neuropathological
conditions including Parkinson's disease (PD). However, the importance of store-operated
Ca2+ entry (SOCE) channels in PD remains to be investigated. In the present study, we
have scrutinized the significance of TRPC1 in 1-methyl-4-phenyl-1, 2, 3, 6-tetrahyrdro-
pyridine (MPTP)-induced PD using C57BL/6 animal model and PC12 cell culture model.
Both sub-acute and sub-chronic treatments of MPTP significantly reduced TRPC1, and …
conditions including Parkinson's disease (PD). However, the importance of store-operated
Ca2+ entry (SOCE) channels in PD remains to be investigated. In the present study, we
have scrutinized the significance of TRPC1 in 1-methyl-4-phenyl-1, 2, 3, 6-tetrahyrdro-
pyridine (MPTP)-induced PD using C57BL/6 animal model and PC12 cell culture model.
Both sub-acute and sub-chronic treatments of MPTP significantly reduced TRPC1, and …