[HTML][HTML] Strong induction of PCSK9 gene expression through HNF1α and SREBP2: mechanism for the resistance to LDL-cholesterol lowering effect of statins in …
B Dong, M Wu, H Li, FB Kraemer, K Adeli… - Journal of lipid …, 2010 - ASBMB
We investigated the role of proprotein convertase subtilisin/kexin type 9 (PCSK9) in the
resistance of dyslipidemic hamsters to statin-induced LDL-cholesterol (LDL-C) reduction
and the molecular mechanism by which statins modulated PCSK9 gene expression in vivo.
We utilized the fructose diet-induced dyslipidemic hamsters as an in vivo model and
rosuvastatin to examine its effects on liver PCSK9 and LDL receptor (LDLR) expression and
serum lipid levels. We showed that rosuvastatin induced PCSK9 mRNA to a greater extent …
resistance of dyslipidemic hamsters to statin-induced LDL-cholesterol (LDL-C) reduction
and the molecular mechanism by which statins modulated PCSK9 gene expression in vivo.
We utilized the fructose diet-induced dyslipidemic hamsters as an in vivo model and
rosuvastatin to examine its effects on liver PCSK9 and LDL receptor (LDLR) expression and
serum lipid levels. We showed that rosuvastatin induced PCSK9 mRNA to a greater extent …
