[HTML][HTML] Rapamycin inhibits protein kinase C activity and stimulates Na+ transport in A6 cells
MD Rokaw, M West, JP Johnson - Journal of Biological Chemistry, 1996 - ASBMB
Rapamycin and FK506 have unique cellular effects despite the fact that they bind to the
same set of immunophilins, the FK506 binding proteins (FKBP). We have previously
reported that rapamycin (RAP) stimulates sodium transport in A6 cells. FK506 did not
stimulate sodium transport but did inhibit the stimulation seen in RAP-treated cells. Since
FKBP12 has been shown to have sequence homology with an endogenous inhibitor of
protein kinase C (PKC) and PKC inhibition has been shown to increase Na+ channel activity …
same set of immunophilins, the FK506 binding proteins (FKBP). We have previously
reported that rapamycin (RAP) stimulates sodium transport in A6 cells. FK506 did not
stimulate sodium transport but did inhibit the stimulation seen in RAP-treated cells. Since
FKBP12 has been shown to have sequence homology with an endogenous inhibitor of
protein kinase C (PKC) and PKC inhibition has been shown to increase Na+ channel activity …
