[HTML][HTML] Insulin receptor dysfunction impairs cellular clearance of neurotoxic oligomeric Aβ
WQ Zhao, PN Lacor, H Chen, MP Lambert… - Journal of Biological …, 2009 - ASBMB
Accumulation of amyloid β (Aβ) oligomers in the brain is toxic to synapses and may play an
important role in memory loss in Alzheimer disease. However, how these toxins are built up
in the brain is not understood. In this study we investigate whether impairments of insulin
and insulin-like growth factor-1 (IGF-1) receptors play a role in aggregation of Aβ. Using
primary neuronal culture and immortal cell line models, we show that expression of normal
insulin or IGF-1 receptors confers cells with abilities to reduce exogenously applied Aβ …
important role in memory loss in Alzheimer disease. However, how these toxins are built up
in the brain is not understood. In this study we investigate whether impairments of insulin
and insulin-like growth factor-1 (IGF-1) receptors play a role in aggregation of Aβ. Using
primary neuronal culture and immortal cell line models, we show that expression of normal
insulin or IGF-1 receptors confers cells with abilities to reduce exogenously applied Aβ …