[HTML][HTML] Phosphorylation of Insulin Receptor Substrate-1 on Multiple Serine Residues, 612, 632, 662, and 731, Modulates Insulin Action (∗)
I Mothe, E Van Obberghen - Journal of Biological Chemistry, 1996 - ASBMB
Okadaic acid has been described previously as being a negative regulator of insulin
signaling, as it inhibits insulin stimulation of glucose transport. In addition, this drug induces
on insulin receptor substrate-1 (IRS-1) a decrease in tyrosine phosphorylation,
concomitantly with an increase in serine/threonine phosphorylation. The present work was
aimed at the identification of the serine/threonine residues that, upon phosphorylation, might
be involved in modulating insulin signaling. To this end, we studied double-point mutants of …
signaling, as it inhibits insulin stimulation of glucose transport. In addition, this drug induces
on insulin receptor substrate-1 (IRS-1) a decrease in tyrosine phosphorylation,
concomitantly with an increase in serine/threonine phosphorylation. The present work was
aimed at the identification of the serine/threonine residues that, upon phosphorylation, might
be involved in modulating insulin signaling. To this end, we studied double-point mutants of …
