[HTML][HTML] Dephosphorylation by default, a potential mechanism for regulation of insulin receptor substrate-1/2, Akt, and ERK1/2
R Zhande, W Zhang, Y Zheng, E Pendleton, Y Li… - Journal of biological …, 2006 - ASBMB
Protein phosphorylation is an important mechanism that controls many cellular activities.
Phosphorylation of a given protein is precisely controlled by two opposing biochemical
reactions catalyzed by protein kinases and protein phosphatases. How these two opposing
processes are coordinated to achieve regulation of protein phosphorylation is unresolved.
We have developed a novel experimental approach to directly study protein
dephosphorylation in cells. We determined the kinetics of dephosphorylation of insulin …
Phosphorylation of a given protein is precisely controlled by two opposing biochemical
reactions catalyzed by protein kinases and protein phosphatases. How these two opposing
processes are coordinated to achieve regulation of protein phosphorylation is unresolved.
We have developed a novel experimental approach to directly study protein
dephosphorylation in cells. We determined the kinetics of dephosphorylation of insulin …