The role of GLP-1 in neuronal activity and neurodegeneration

C Hölscher - Vitamins & Hormones, 2010 - Elsevier
Type 2 diabetes has been identified as a risk factor for Alzheimer's disease (AD). The
underlying mechanism behind this unexpected link is most likely linked to the observed
desensitization of insulin receptors in the brain. Insulin acts as a growth factor in the brain
and supports neuronal repair, dendritic sprouting, and differentiation. Several drugs have
been developed to treat type 2 diabetes which resensitize insulin receptors and may be of
use to prevent neurodegenerative developments in AD. The incretin glucagon-like peptide-1 …