Insulin resistance is a feature of a number of clinical disorders, including type 2
diabetes/glucose intolerance, obesity, dyslipidaemia and hypertension clustering in the so-
called metabolic syndrome. Insulin resistance in skeletal muscle manifests itself primarily as
a reduction in insulin-stimulated glycogen synthesis due to reduced glucose transport.
Ectopic lipid accumulation plays an important role in inducing insulin resistance. Multiple
defects in insulin signalling are responsible for impaired glucose metabolism in target …