Meta-analysis of Alzheimer's disease risk with obesity, diabetes, and related disorders
LA Profenno, AP Porsteinsson, SV Faraone - Biological psychiatry, 2010 - Elsevier
BACKGROUND: Late-onset Alzheimer's disease (AD) is a multifactorial and heterogeneous
disorder with major risk factors including advanced age, presence of an apolipoprotein E ε4
(APOE4) allele, and family history of AD. Other risk factors may be obesity and diabetes and
related disorders, which are highly prevalent. METHODS: We reviewed longitudinal
epidemiological studies of body mass, diabetes, metabolic syndrome, and glucose and
insulin levels on risk for AD. We conducted meta-analyses of the results from these studies …
disorder with major risk factors including advanced age, presence of an apolipoprotein E ε4
(APOE4) allele, and family history of AD. Other risk factors may be obesity and diabetes and
related disorders, which are highly prevalent. METHODS: We reviewed longitudinal
epidemiological studies of body mass, diabetes, metabolic syndrome, and glucose and
insulin levels on risk for AD. We conducted meta-analyses of the results from these studies …