Involvement of Src family kinase activation in angiotensin II-induced hyperresponsiveness of rat bronchial smooth muscle
H Sakai, A Nishimura, Y Watanabe, Y Nishizawa… - Peptides, 2010 - Elsevier
Angiotensin II (Ang II) might be an important mediator in pathogenesis of airway
hyperresponsiveness (AHR) that is the asthmatic characteristic feature of asthma, although
the mechanisms of AHR caused by Ang II are not yet clear. Presently, the RT-PCR analyses
revealed that all the Src family kinases (SFKs), such as Fyn, Lck, Lyn, Hck, Src, Yes, Blk, Fgr
and Frk, were expressed in the lungs and main bronchi of rats. The phosphorylation
(activation) of SFK (Tyr416) was increased in bronchial smooth muscle (BSM) by Ang II. The …
hyperresponsiveness (AHR) that is the asthmatic characteristic feature of asthma, although
the mechanisms of AHR caused by Ang II are not yet clear. Presently, the RT-PCR analyses
revealed that all the Src family kinases (SFKs), such as Fyn, Lck, Lyn, Hck, Src, Yes, Blk, Fgr
and Frk, were expressed in the lungs and main bronchi of rats. The phosphorylation
(activation) of SFK (Tyr416) was increased in bronchial smooth muscle (BSM) by Ang II. The …