[HTML][HTML] Obligatory role of Src kinase in the signaling mechanism for TRPC3 cation channels
G Vazquez, BJ Wedel, BT Kawasaki, GSJ Bird… - Journal of Biological …, 2004 - ASBMB
Members of the canonical transient receptor potential (TRPC) subfamily of cation channels
are candidates for capacitative and non-capacitative Ca 2+ entry channels. When
ectopically expressed in cell lines, TRPC3 can be activated by phospholipase C-mediated
generation of diacylglycerol or by addition of synthetic diacylglycerols, independently of Ca
2+ store depletion. Apart from this mode of regulation, little is known about other receptor-
dependent signaling events that modulate TRPC3 activity. In the present study the role of …
are candidates for capacitative and non-capacitative Ca 2+ entry channels. When
ectopically expressed in cell lines, TRPC3 can be activated by phospholipase C-mediated
generation of diacylglycerol or by addition of synthetic diacylglycerols, independently of Ca
2+ store depletion. Apart from this mode of regulation, little is known about other receptor-
dependent signaling events that modulate TRPC3 activity. In the present study the role of …