[HTML][HTML] Regulation of TRPC6 channel activity by tyrosine phosphorylation
C Hisatsune, Y Kuroda, K Nakamura, T Inoue… - Journal of Biological …, 2004 - ASBMB
Various hormonal stimuli and growth factors activate the mammalian canonical transient
receptor potential (TRPC) channel through phospholipase C (PLC) activation. However, the
precise mechanism of the regulation of TRPC channel activity remains unknown. Here, we
provide the first evidence that direct tyrosine phosphorylation by Src family protein-tyrosine
kinases (PTKs) is a novel mechanism for modulating TRPC6 channel activity. We found that
TRPC6 is tyrosine-phosphorylated in COS-7 cells when coexpressed with Fyn, a member of …
receptor potential (TRPC) channel through phospholipase C (PLC) activation. However, the
precise mechanism of the regulation of TRPC channel activity remains unknown. Here, we
provide the first evidence that direct tyrosine phosphorylation by Src family protein-tyrosine
kinases (PTKs) is a novel mechanism for modulating TRPC6 channel activity. We found that
TRPC6 is tyrosine-phosphorylated in COS-7 cells when coexpressed with Fyn, a member of …