Over-expression of IL-33 leads to spontaneous pulmonary inflammation in mIL-33 transgenic mice
X Zhiguang, C Wei, R Steven, D Wei, Z Wei, M Rong… - Immunology letters, 2010 - Elsevier
IL-33 plays an important role in inflammatory diseases including hypersensitive diseases
like asthma, autoimmune diseases like rheumatoid arthritis, cardiovascular diseases like
heart failure and neurodegenerative diseases like Alzheimer's disease. Here we reported
the generation of an IL-33 transgenic mouse, in which mouse IL-33 full-length cDNA was
controlled under the CMV promoter. The transgenic IL-33 was released as a cleaved form
with molecular weight of 18kDa in pulmonary, nephritic, cardiac and pancreatic tissues in …
like asthma, autoimmune diseases like rheumatoid arthritis, cardiovascular diseases like
heart failure and neurodegenerative diseases like Alzheimer's disease. Here we reported
the generation of an IL-33 transgenic mouse, in which mouse IL-33 full-length cDNA was
controlled under the CMV promoter. The transgenic IL-33 was released as a cleaved form
with molecular weight of 18kDa in pulmonary, nephritic, cardiac and pancreatic tissues in …