BACKGROUND: Treatment-resistant major depressive disorder is a prevalent and
debilitating condition. Deep brain stimulation to different targets has been proposed as a
putative treatment. METHODS: In this pilot study, we assessed safety and efficacy of deep
brain stimulation to the supero-lateral branch of the medial forebrain bundle in seven
patients with highly refractory depression. Primary outcome criterion was severity of
treatment-resistant major depressive disorder as assessed with the Montgomery-Åsberg …