The promise of human induced pluripotent stem cells for research and therapy
S Nishikawa, RA Goldstein, CR Nierras - Nature reviews Molecular cell …, 2008 - nature.com
S Nishikawa, RA Goldstein, CR Nierras
Nature reviews Molecular cell biology, 2008•nature.comInduced pluripotent stem (iPS) cells are human somatic cells that have been reprogrammed
to a pluripotent state. There are several hurdles to be overcome before iPS cells can be
considered as a potential patient-specific cell therapy, and it will be crucial to characterize
the developmental potential of human iPS cell lines. As a research tool, iPS-cell technology
provides opportunities to study normal development and to understand reprogramming. iPS
cells can have an immediate impact as models for human diseases, including cancer.
to a pluripotent state. There are several hurdles to be overcome before iPS cells can be
considered as a potential patient-specific cell therapy, and it will be crucial to characterize
the developmental potential of human iPS cell lines. As a research tool, iPS-cell technology
provides opportunities to study normal development and to understand reprogramming. iPS
cells can have an immediate impact as models for human diseases, including cancer.
Abstract
Induced pluripotent stem (iPS) cells are human somatic cells that have been reprogrammed to a pluripotent state. There are several hurdles to be overcome before iPS cells can be considered as a potential patient-specific cell therapy, and it will be crucial to characterize the developmental potential of human iPS cell lines. As a research tool, iPS-cell technology provides opportunities to study normal development and to understand reprogramming. iPS cells can have an immediate impact as models for human diseases, including cancer.
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