The reversible acetylation of histones and non-histone proteins by histone
acetyltransferases and deacetylases (HDACs) plays a critical role in many cellular
processes in eukaryotic cells. HDAC6 is a unique histone deacetylase with two deacetylase
domains and a C-terminal zinc finger domain. HDAC6 resides mainly in the cytoplasm and
regulates many important biological processes, including cell migration and degradation of
misfold proteins. HDAC6 has also been shown to localize in the nucleus to regulate …