HDAC 6 at the intersection of neuroprotection and neurodegeneration
C d'Ydewalle, E Bogaert, L Van Den Bosch - Traffic, 2012 - Wiley Online Library
C d'Ydewalle, E Bogaert, L Van Den Bosch
Traffic, 2012•Wiley Online LibraryHistone deacetylase 6 (HDAC 6) catalyzes multiple reactions. We summarize the current
knowledge on HDAC 6, its targets and functions. Among others, HDAC 6 recognizes
damaged proteins and assures that these proteins are destroyed by autophagy. On the other
hand, HDAC 6 also modifies the tracks used by the clearance mechanism so that axonal
transport becomes less efficient. We hypothesize that a disturbance in the equilibrium
between the different functions of HDAC 6 could play an important role in …
knowledge on HDAC 6, its targets and functions. Among others, HDAC 6 recognizes
damaged proteins and assures that these proteins are destroyed by autophagy. On the other
hand, HDAC 6 also modifies the tracks used by the clearance mechanism so that axonal
transport becomes less efficient. We hypothesize that a disturbance in the equilibrium
between the different functions of HDAC 6 could play an important role in …
Histone deacetylase 6 (HDAC6) catalyzes multiple reactions. We summarize the current knowledge on HDAC6, its targets and functions. Among others, HDAC6 recognizes damaged proteins and assures that these proteins are destroyed by autophagy. On the other hand, HDAC6 also modifies the tracks used by the clearance mechanism so that axonal transport becomes less efficient. We hypothesize that a disturbance in the equilibrium between the different functions of HDAC6 could play an important role in neurodegeneration.
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