Molecular cloning and expression of rat torsinA in the normal and genetically dystonic (dt) rat
P Ziefer, J Leung, T Razzano, C Shalish… - Molecular brain …, 2002 - Elsevier
Deletions within the TOR1A gene cause early-onset (DYT1) torsion dystonia. We have
cloned and sequenced the rat cDNA homologue of TOR1A and found a 91% identity with
the human sequence. Northern blot analysis detects a single transcript of approximately 1.5
kb. In situ hybridization reveals a widespread distribution of torsinA mRNA within brain. No
mutations were identified in the coding region of the gene in the genetically dystonic (dt) rat.
cloned and sequenced the rat cDNA homologue of TOR1A and found a 91% identity with
the human sequence. Northern blot analysis detects a single transcript of approximately 1.5
kb. In situ hybridization reveals a widespread distribution of torsinA mRNA within brain. No
mutations were identified in the coding region of the gene in the genetically dystonic (dt) rat.