Type-I IFN signaling is required for the induction of antigen-specific CD8+ T cell responses by adenovirus vector vaccine in the gut-mucosa
M Shoji, M Tachibana, K Katayama, K Tomita… - Biochemical and …, 2012 - Elsevier
M Shoji, M Tachibana, K Katayama, K Tomita, S Tsuzuki, F Sakurai, K Kawabata, KJ Ishii…
Biochemical and Biophysical Research Communications, 2012•ElsevierAdenovirus vector (Adv) vaccination at a systemic site, such as intramuscular (im)
immunization, can induce antigen-specific CD8+ T cell responses in both systemic and
mucosal compartments. It remains unclear, however, how antigen-specific CD8+ T cell
response is induced in the mucosa. In this study, we found that type-I IFN signaling is
required for the induction of mRNA expression of retinal dehydrogenase in the draining
lymph nodes following the im Adv vaccination. We show that type-I IFN signaling is required …
immunization, can induce antigen-specific CD8+ T cell responses in both systemic and
mucosal compartments. It remains unclear, however, how antigen-specific CD8+ T cell
response is induced in the mucosa. In this study, we found that type-I IFN signaling is
required for the induction of mRNA expression of retinal dehydrogenase in the draining
lymph nodes following the im Adv vaccination. We show that type-I IFN signaling is required …
Adenovirus vector (Adv) vaccination at a systemic site, such as intramuscular (i.m.) immunization, can induce antigen-specific CD8+ T cell responses in both systemic and mucosal compartments. It remains unclear, however, how antigen-specific CD8+ T cell response is induced in the mucosa. In this study, we found that type-I IFN signaling is required for the induction of mRNA expression of retinal dehydrogenase in the draining lymph nodes following the i.m. Adv vaccination. We show that type-I IFN signaling is required for the induction of antigen-specific CD8+ T cell response in the gut-mucosal compartment following the i.m. Adv vaccination.
Elsevier