Prediction of MHC class I binding peptides using profile motifs
PA Reche, JP Glutting, EL Reinherz - Human immunology, 2002 - Elsevier
Peptides that bind to a given major histocompatibility complex (MHC) molecule share
sequence similarity. Therefore, a position specific scoring matrix (PSSM) or profile derived
from a set of peptides known to bind to a specific MHC molecule would be a suitable
predictor of whether other peptides might bind, thus anticipating possible T-cell epitopes
within a protein. In this approach, the binding potential of any peptide sequence (query) to a
given MHC molecule is linked to its similarity to a group of aligned peptides known to bind to …
sequence similarity. Therefore, a position specific scoring matrix (PSSM) or profile derived
from a set of peptides known to bind to a specific MHC molecule would be a suitable
predictor of whether other peptides might bind, thus anticipating possible T-cell epitopes
within a protein. In this approach, the binding potential of any peptide sequence (query) to a
given MHC molecule is linked to its similarity to a group of aligned peptides known to bind to …