The role of heat shock protein 27 in bronchiolitis obliterans syndrome after lung transplantation
KL Wood, DR Nunley, S Moffatt-Bruce… - The Journal of heart and …, 2010 - Elsevier
BACKGROUND: Heat shock proteins (Hsps) are a family of evolutionary conserved proteins
classified according to their size as small and large Hsps. They have a cytoprotective role
and have been shown to be immunogenic molecules. In addition, self-reactivity to Hsps has
been implicated in various autoimmune diseases and in the development of alloimmunity.
This study examined the relationship of large and small Hsps and anti-Hsp antibodies in
lung transplant (LTx) recipients who have bronchiolitis obliterans syndrome (BOS) …
classified according to their size as small and large Hsps. They have a cytoprotective role
and have been shown to be immunogenic molecules. In addition, self-reactivity to Hsps has
been implicated in various autoimmune diseases and in the development of alloimmunity.
This study examined the relationship of large and small Hsps and anti-Hsp antibodies in
lung transplant (LTx) recipients who have bronchiolitis obliterans syndrome (BOS) …