Analysis of pregnancy-induced anti-HLA antibodies using Luminex platform
M Vilches, A Nieto - Transplantation proceedings, 2015 - Elsevier
Background The impact of pregnancy on the incidence of HLA sensitization is poorly
explored, and most of the data were obtained by use of a complement-dependent
cytotoxicity (CDC) assay with an incidence of 18% to 30%. In many cases, antibodies cannot
be detected by CDC as their level fades in time. However, this state of “latent” sensitization
can still have a significant clinical impact in a subsequent transplantation setting. Methods
Pregnancy-induced HLA sensitization was analyzed in 69 mothers without a history of …
explored, and most of the data were obtained by use of a complement-dependent
cytotoxicity (CDC) assay with an incidence of 18% to 30%. In many cases, antibodies cannot
be detected by CDC as their level fades in time. However, this state of “latent” sensitization
can still have a significant clinical impact in a subsequent transplantation setting. Methods
Pregnancy-induced HLA sensitization was analyzed in 69 mothers without a history of …
