Control of regulatory T cells by co-signal molecules
JB Wing, C Tay, S Sakaguchi - Co-signal Molecules in T Cell Activation …, 2019 - Springer
JB Wing, C Tay, S Sakaguchi
Co-signal Molecules in T Cell Activation: Immune Regulation in Health and Disease, 2019•SpringerFoxp3-expressing regulatory T cells (Tregs) perform a vital function in the maintenance of
immune homeostasis. A large part of Treg suppressive function is derived from their ability to
control and restrict the availability of co-signal molecules to other T cells. However, Tregs
themselves also depend on many of the same co-signals for their own homeostasis, making
this a complex system of feedback. In this chapter, we discuss the critical role of co-signaling
in Treg cell biology.
immune homeostasis. A large part of Treg suppressive function is derived from their ability to
control and restrict the availability of co-signal molecules to other T cells. However, Tregs
themselves also depend on many of the same co-signals for their own homeostasis, making
this a complex system of feedback. In this chapter, we discuss the critical role of co-signaling
in Treg cell biology.
Abstract
Foxp3-expressing regulatory T cells (Tregs) perform a vital function in the maintenance of immune homeostasis. A large part of Treg suppressive function is derived from their ability to control and restrict the availability of co-signal molecules to other T cells. However, Tregs themselves also depend on many of the same co-signals for their own homeostasis, making this a complex system of feedback. In this chapter, we discuss the critical role of co-signaling in Treg cell biology.
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