Discovery, development, and future application of senolytics: theories and predictions
EO Wissler Gerdes, Y Zhu, T Tchkonia… - The FEBS …, 2020 - Wiley Online Library
EO Wissler Gerdes, Y Zhu, T Tchkonia, JL Kirkland
The FEBS journal, 2020•Wiley Online LibrarySenescent cells accumulate with aging and at etiological sites of multiple diseases,
including those accounting for most morbidity, mortality, and health costs. Senescent cells
do not replicate, can release factors that cause tissue dysfunction, and yet remain viable.
The discovery of senolytic drugs, agents that selectively eliminate senescent cells, created a
new route for alleviating age‐related dysfunction and diseases. As anticipated for agents
targeting fundamental aging mechanisms that are 'root cause'contributors to multiple …
including those accounting for most morbidity, mortality, and health costs. Senescent cells
do not replicate, can release factors that cause tissue dysfunction, and yet remain viable.
The discovery of senolytic drugs, agents that selectively eliminate senescent cells, created a
new route for alleviating age‐related dysfunction and diseases. As anticipated for agents
targeting fundamental aging mechanisms that are 'root cause'contributors to multiple …
Senescent cells accumulate with aging and at etiological sites of multiple diseases, including those accounting for most morbidity, mortality, and health costs. Senescent cells do not replicate, can release factors that cause tissue dysfunction, and yet remain viable. The discovery of senolytic drugs, agents that selectively eliminate senescent cells, created a new route for alleviating age‐related dysfunction and diseases. As anticipated for agents targeting fundamental aging mechanisms that are ‘root cause’ contributors to multiple disorders, potential applications of senolytics are protean. We review the discovery of senolytics, strategies for translation into clinical application, and promising early signals from clinical trials.
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